Rosalyn Yalow(1921 — 2011)

Rosalyn Yalow

États-Unis

6 min read

Sciences20th CenturyTwentieth-century United States, the golden age of postwar biomedical research and the rise of medical applications of radioactivity.

Rosalyn Yalow was an American medical physicist and a pioneer of nuclear medicine. With Solomon Berson, she developed the radioimmunoassay (RIA), a technique that revolutionized biological diagnostics. She received the Nobel Prize in Medicine in 1977.

Frequently asked questions

Rosalyn Yalow (1921-2011) was an American medical physicist, best known for developing the radioimmunoassay (RIA) in 1959 with Solomon Berson. The key takeaway is that this technique revolutionized medical diagnosis by making it possible to measure hormones and other substances in the blood at tiny concentrations that had been undetectable until then. She received the Nobel Prize in Medicine in 1977 for this discovery, becoming the second woman to win that award in the discipline.

Famous Quotes

« We must believe in ourselves or no one else will believe in us. »

Key Facts

  • Born on July 19, 1921, in the Bronx, New York
  • Developed the radioimmunoassay (RIA) with Solomon Berson in the 1950s
  • First application of RIA to measure insulin in human blood (1959-1960)
  • Received the Nobel Prize in Physiology or Medicine in 1977, the second woman to win it
  • Died on May 30, 2011, in New York

Works & Achievements

Creation of the radioisotope service at the Bronx Veterans Affairs Hospital (1947)

She founded one of the first nuclear medicine departments, which would become a world-renowned research laboratory.

Discovery of anti-insulin antibodies in diabetics (1956)

With Berson, she demonstrated that the body produces antibodies against injected insulin, an idea at first rejected by the major scientific journals.

Radioimmunoassay (RIA) (1959)

Her major achievement: a technique capable of measuring hormones and other substances in minuscule quantities in the blood, which revolutionized medical diagnosis.

“Assay of plasma insulin in human subjects by immunological methods” (Nature) (1959)

Foundational paper presenting the method for measuring insulin in human blood.

Refusal to patent the RIA (1959)

A choice not to file a patent so that the technique could spread freely around the world and benefit every patient.

Albert Lasker Award for Basic Medical Research (1976)

The first woman to receive this prestigious distinction, often seen as an antechamber to the Nobel Prize.

Nobel Prize in Medicine (1977)

An award honoring the development of the radioimmunoassay of peptide hormones; she was the second woman to receive this Nobel Prize.

National Medal of Science (1988)

The highest American scientific distinction, awarded for her body of work as a whole.

Anecdotes

As a teenager, Rosalyn devours the biography of Marie Curie written by her daughter Ève Curie. This book, which tells the story of a woman rejected and then triumphant in science, becomes her role model and convinces her that she too can become a physicist, even though it was a profession almost forbidden to women.

When she earns an assistantship scholarship at the University of Illinois in 1941, she is the only woman among the hundreds of teachers and researchers in the college of engineering, and the first since 1917. The war, which had sent so many young men to the front, opened a door usually closed to her.

At first, for lack of space, Rosalyn Yalow and Solomon Berson set up their radioisotope laboratory at the Bronx Veterans Administration hospital in a converted former janitor's closet. It is in this tiny room that a technique destined to change medicine worldwide would be born.

With Berson, she refuses to patent the radioimmunoassay (RIA). Rather than make money, they choose to freely share their invention so that laboratories all over the world can use it and save lives.

Solomon Berson, her research partner, dies in 1972. Since the Nobel Prize is never awarded posthumously, Rosalyn receives it alone in 1977. She never forgets her colleague: she names their laboratory after him and mentions him in all her speeches.

Primary Sources

Nobel Banquet Speech, Rosalyn Yalow, Stockholm (December 10, 1977)
The world cannot afford to lose the talents of half its people if we are to solve the many problems that beset us.
Nobel Lecture — “Radioimmunoassay: A Probe for the Fine Structure of Biologic Systems” (December 8, 1977)
Radioimmunoassay makes it possible to measure substances present in the blood at minuscule concentrations, until then completely undetectable.
Yalow R. & Berson S., “Assay of plasma insulin in human subjects by immunological methods,” Nature (1959)
An immunological method makes it possible to measure the amount of insulin circulating in the plasma of human subjects.
Berson S. & Yalow R., “Insulin-I131 metabolism in human subjects,” Journal of Clinical Investigation (1956)
Diabetic patients treated with insulin develop antibodies in their blood capable of binding to the injected hormone.
Yalow R. & Berson S., “Immunoassay of endogenous plasma insulin in man,” Journal of Clinical Investigation (1960)
The immunoassay of insulin naturally produced by the body opens a new path for the study of hormones.

Key Places

The Bronx, New York

Working-class neighborhood of New York where Rosalyn was born in 1921 and where she spent most of her life and career.

Hunter College, New York

Free public university for women where she studied physics and chemistry, the first in her family to pursue higher education.

University of Illinois at Urbana-Champaign

University where she earned her PhD in physics in 1945, the only woman on the engineering faculty.

Bronx Veterans Hospital (Bronx VA Medical Center)

Hospital where she set up a radioisotope unit and developed the radioimmunoassay together with Solomon Berson.

See also